Klinefelter Syndrome and Metabolic Disorder

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Klinefelter Syndrome and Metabolic Disorder

Hypogonadism is reported to be an independent risk factor for the development of central obesity in men, and epidemiologic studies indicate an inverse relation between serum testosterone and obesity [1]. In patients with prostate cancer, androgen deprivation therapies increased body fat mass [2], whereas it is known that androgen can prevent the differentiation of pluripotent cells into an adip...

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Klinefelter syndrome

Some males with Klinefelter syndrome have the extra X chromosome only in some of their cells (mosaic Klinefelter syndrome). In addition, 46,XX males also exist and it is caused by translocation of Y material including sex determining region (SRY) to the X chromosome during paternal meiosis. Formal cytogenetic analysis is necessary to make a definite diagnosis, and more obvious differences in ph...

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Klinefelter syndrome

Some males with Klinefelter syndrome have the extra X chromosome only in some of their cells (mosaic Klinefelter syndrome). In addition, 46,XX males also exist and it is caused by translocation of Y material including sex determining region (SRY) to the X chromosome during paternal meiosis. Formal cytogenetic analysis is necessary to make a definite diagnosis, and more obvious differences in ph...

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Klinefelter syndrome

Some males with Klinefelter syndrome have the extra X chromosome only in some of their cells (mosaic Klinefelter syndrome). In addition, 46,XX males also exist and it is caused by translocation of Y material including sex determining region (SRY) to the X chromosome during paternal meiosis. Formal cytogenetic analysis is necessary to make a definite diagnosis, and more obvious differences in ph...

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Klinefelter syndrome.

To complement the 2005 Annual Clinical Focus on medical genomics, AFP is publishing a series of short reviews on genetic syndromes. This series was designed to increase awareness of these diseases so that family physicians can recognize and diagnose children with these disorders and understand the kind of care they might require in the future. This review discusses Klinefelter syndrome.

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ژورنال

عنوان ژورنال: Endocrinology and Metabolism

سال: 2016

ISSN: 2093-596X,2093-5978

DOI: 10.3803/enm.2016.31.4.535